Palladium-catalyzed decarboxylative acylation of O-methyl ketoximes with α-keto acids.
نویسندگان
چکیده
A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range of O-methyl ketoximes and α-keto acids undergoes the decarboxylative cross-coupling reactions with high selectivities and good tolerance.
منابع مشابه
Palladium-catalyzed decarboxylative acylation of O-methyl ketoximes with a-keto acids†
Aryl ketones are important structural motifs found in natural products, medicinally relevantmolecules, and functionalmaterials. In particular, 1,2-diacylbenzenes are known to be crucial synthetic precursors to construct a wide range of biologically active compounds including phthalazines, phthalimidines, isobenzofuranes, indanones, isoindoles, and isoindolines. These facts have led to increasin...
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 9 شماره
صفحات -
تاریخ انتشار 2013